ea0092op-07-04 | Oral Session 7: Thyroid hormone receptors | ETA2023
Harting Nina
, Sebastian Hones G.
, Eckhold Juliane
, Kilpert Fabian
, Gemoll Timo
, Mittag Jens
, Kaiser Frank J.
Objectives: The canonical function of thyroid hormone receptors (TRs) as mediators of thyroid hormone action on target gene expression is well known. However, the physiological function of the thyroid hormone receptor α splice variant TRα2, that does not bind thyroid hormones, remains elusive. Initial studies addressing the function of TRα2 indicated that it might act as a TRα1 antagonist, but the mechanisms underlying the dominant-negative activity of TR&#...